Anti-inflammatory Drugs For Depression

The treatment of depression with antidepressants and cognitive therapy has a 60% success rate. Patients may seek other therapeutic alternatives, such as anti-inflammatory drugs, to treat this condition.
Anti-inflammatory drugs for depression

For some time now, many researchers have focused their studies on why people suffer from inflammation during depressive episodes. In this article, you’ll learn about the potential therapeutic benefits of using anti-inflammatory drugs to treat depression.

According to some studies, the conventional treatment of depression consists of the use of antidepressants and cognitive therapy, but this is only effective in about 60% of patients. This means that 40% of patients do not benefit from this treatment. It is worth noting that a depressive state can sometimes end in suicide.

In major depression, this is a high percentage of patients without effective treatment. Depression affects more than 350 million people in the world, which amounts to 1 in every 10 adults. In short, depression is a complex topic and people should look for therapeutic alternatives that can help treat this disorder.

anti-inflammatory drugs

Inflammation and its relationship with depression

As we mentioned above, more and more studies are establishing the link between depression and inflammatory states of the brain. Initially, it was not clear whether depression could be a result of inflammation or whether depression was the cause of the inflammatory state.

In a broader sense, depression is a multifactorial disorder, linking different psychosocial, genetic and biological aspects. Stress can also be an inflammatory factor. In summary, we can say that these aspects, along with stress, send inflammatory signals to the brain.

Some patients with major depression show more signs of inflammation in their blood. These signs include pro-inflammatory cytokines, which are capable of altering the central nervous system and neuroendocrine system.

Also, the amounts of C-reactive protein in your body can increase, as can some interleukins.

The use of anti-inflammatory drugs for depression

The theory of inflammation and depression thus opens up a range of therapeutic alternatives that can help treat this condition. This is especially important for patients who do not respond to the more conventional antidepressants.

The inhibition of pro-inflammatory cytokines (Spanish link) improves the efficacy of antidepressants and thus improves the mental state of patients suffering from depression.

This relationship was discovered thanks to oncological and anti-infective treatments. During these treatments, the doctors found that administering interferon alpha to patients caused them to have depression-like symptoms.

A bowl of oil, a cut open avocado, a slice of salmon and a bowl of nuts

Today, more and more researchers are studying the actual therapeutic benefits of using anti-inflammatory drugs in the treatment of depression.

Several animal studies have shown that taking pro-inflammatory cytokine blockers reduces depressive behavior and other responses to stress.

These pro-inflammatory cytokine blockers, also called anti-inflammatory cytokines or anti-cytokines, are sometimes used in patients with autoimmune diseases, such as rheumatoid arthritis or psoriasis. Studies have shown that this therapy can have a significant effect in patients compared to placebos.

Omega-3 as a complementary treatment against depression

Certain studies suggest omega 3 supplements as a therapeutic alternative, thanks to its anti-inflammatory effect. Several studies attribute the depressive state to a lack of omega-3 polyunsaturated fatty acids.

Omega 3 fatty acids appear to be more effective against major depressive episodes. For example, omega-3 is able to influence your immune system, reduce certain cytokines and inflammatory protaglandins and alter other molecular mechanisms.

A man watches a flight of birds as night falls

These alternatives require more research. So depression is a complex condition and inflammation has too many vague symptoms that make it difficult to make a clear connection between the two. This is also an open therapeutic area with many points of view and much hope for the future.

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